Detalhe da pesquisa
1.
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice.
Arch Toxicol
; 2024 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38551724
2.
Development of a clinically relevant ex vivo model of cardiac ablation for testing of ablation catheters.
J Cardiovasc Electrophysiol
; 34(3): 682-692, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36482158
3.
JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction.
Regul Toxicol Pharmacol
; : 105480, 2023 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37625518
4.
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
Regul Toxicol Pharmacol
; : 105334, 2023 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36608923
5.
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.
Regul Toxicol Pharmacol
; : 105379, 2023 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36931586
6.
First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen.
Regul Toxicol Pharmacol
; 134: 105236, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35934140
7.
Site-specific cancer risk following cobalt exposure via orthopedic implants or in occupational settings: A systematic review and meta-analysis.
Regul Toxicol Pharmacol
; 129: 105096, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896478
8.
A systematic assessment of the epidemiologic literature regarding an association between acetaminophen exposure and cancer.
Regul Toxicol Pharmacol
; 127: 105043, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34517075
9.
A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential.
Regul Toxicol Pharmacol
; 122: 104892, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33592196
10.
Carcinogenic assessment of cobalt-containing alloys in medical devices or cobalt in occupational settings: A systematic review and meta-analysis of overall cancer risk from published epidemiologic studies.
Regul Toxicol Pharmacol
; 125: 104987, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34229014
11.
A hazard evaluation of the reproductive/developmental toxicity of cobalt in medical devices.
Regul Toxicol Pharmacol
; 123: 104932, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872739
12.
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential.
Regul Toxicol Pharmacol
; 120: 104859, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33388367
13.
An integrated benefit-risk assessment of cobalt-containing alloys used in medical devices: Implications for regulatory requirements in the European Union.
Regul Toxicol Pharmacol
; 125: 105004, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34256083
14.
Carcinogenic hazard assessment of cobalt-containing alloys in medical devices: Review of in vivo studies.
Regul Toxicol Pharmacol
; 122: 104910, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33662479
15.
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.
Regul Toxicol Pharmacol
; 118: 104788, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33153971
16.
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential.
Regul Toxicol Pharmacol
; 118: 104801, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33039518
17.
Effect of Opioids on Testosterone Levels: Cross-Sectional Study using NHANES.
Pain Med
; 16(12): 2235-42, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26177122
18.
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome.
Res Sq
; 2024 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38463959
19.
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome.
Stem Cell Res Ther
; 15(1): 123, 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38679747
20.
PEGylated thrombopoietin mimetic, JNJ26366821 a novel prophylactic radiation countermeasure for acute radiation injury.
Sci Rep
; 13(1): 15211, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37709916